![]() Thus it was the aim of this study to test extracts and fractions from Valeriana officinalis L. The therapeutic indication given in the ESCOP monograph “relief of temporary mild nervous tension and/or difficulty in falling asleep“ may not only indicate a sedative but rather a tranquillizing effect of such extracts. A sedative effect, which predominantly is assumed to be responsible for efficacy, could not be demonstrated in most clinical studies or pharmacological investigations. Though several clinical studies revealed sleep improving properties of aqueous and ethanolic extracts from Valeriana officinalis L., neither the mode of action is known nor the active constituents are identified.
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